M.
Pharm. (Pharmaceutical Chemistry)
COURSE STRUCTURE AND
SYLLABUS
I YEAR I SEMESTER
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Code
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Group
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Subject
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L
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P
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Credits
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Modern Pharmaceutical Analytical
Techniques
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3
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0
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3
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|
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Advanced biostatistics and research
methods
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3
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0
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3
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Advanced Pharmaceutical Organic Chemistry
– 1
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3
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0
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3
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Advanced Medicinal Chemistry – I
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3
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0
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3
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Advanced Medicinal Chemistry-II
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3
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0
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3
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Lab
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Advanced Pharmaceutical Organic Chemistry
Practical Lab– 1
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0
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3
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2
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Lab
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Advanced Medicinal Chemistry Practical
Lab– I
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0
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3
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2
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|
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Seminar
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-
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-
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2
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Total Credits
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21
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MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
(Common to all Branches)
Unit-I
A detailed study of separations and
determination involved in the following chromatographic techniques.
- Column chromatography : Theory, preparation, procedures, methods of detection.
- This layer chromatography : Theory, preparation, procedures, detection of compounds
- Paper Chromatography : Theory, different techniques employed, filter papers used, quantitative and quantitative detections.
- Counter, current extraction , soild phase extraction techniques.
Unit-II
- Gas chromatography: fundamentals, Instrumentation, columns preparation and operations, detection, derivitasation, LC-MS, GC-MS.
- HPLC : Principles and Instrumentations.
Unit-III
- UV-Visible Spectroscopy : Principle, Beer Lambert’s law, study and working principle of instrumentation, applications in pharmaceutical analysis and derivatives spectroscopy.
- IR Spectroscopy: Theory, different types of molecular vibrations, sampling techniques, instrumentation and applications in pharmaceutical analysis, FTIR
- Flurorimetry : Theory, fluorescence and chemical structure, factors affecting the fluorescence, study of working principles of the instrument and applications in pharmaceutical analysis.
Unit-IV
- NMR : theory, Chemical-shift, spin-spin coupling, shielding, working principle of instrumentations and applications in pharmaceutical analysis, HNMR, and cosy 13CNMR.
- Mass: principle, different methods of production of ions metastable ions, working principle of mass spectrometer and applications in pharmaceutical analysis.
Unit-V
- Differential thermal analysis, partial thermal analysis.
- Radiometric techniques, Radio immunoassay, Elisha test.
- X-ray diffraction, polarimetry.
ADVANCED BIOSTATISTICS
& RESEARCH METHODS
Unit-I :
Developing a research question, Resources
for research question,
Literature Review: Traditional Qualitative
Review
Meta-Analysis—A
Quantitative Review
Preparation of Research Proposal
Variables—Definition of Variable, Types of
variables—Dependent and Independent variables, Confounded variables,
Measurement of variables, Types of measurement scales and their comparison.
Reliability and Validity of Measurements.
Unit-II :
Validity, Types of validity—Internal
validity, Construct validity, External validity, Threats to validity.
Control: Subject as own control (Within
Subject control), Statistical control.
Unit-III:
Non-experimental Research:
Part 1—Observational, Archival and
Case-Study Research: The Hermeneutic Approach.
Observational Research: Naturalistic
Observation, Participant-Observer Research.
Archival Research: Archival Data Collection
and Compilation.
Case Studies: Characteristic of Case Studies.
Non-experimental Research: Survey
Research—Designing of Questionnaire, Methods of Administration, Response
Rates. Types of Samples—Haphazard
Samples, Purposive Samples, Convenience Samples and Probability Samples.
Unit-IV :
True Experiments: Single-Factor Designs,
Factors, Levels, Conditions, and Treatments.
Within-Subject Designs.
True Experiments Part-2—Factorial
Designs—Main Effects, Interactions, A Mixed Factorial Design.
Unit V :
Single-Subject Experiments: Advantages and
Disadvantages.
Quasi Experiments: The differences between
Quasi and True Experiments.
Design without Control Groups—Interrupted
Time Series Designs and Repeated Treatment Designs.
Text
Books
1.
Donald H. McBurney -Theresa L. White
“Research Methods” ( Cengage learning India Pvt. Ltd)
2. Statistics for business and economics 3rd
edition by-Hooda-R.P- MC. Millan Business books
3. Biostatistics & Computer
applications by GN Rao and NK Tiwari
Reference
Books
1. Remingtons pharmaceutical Sciences
2.. Theory & Practice of Industrial
Pharmacy by Lachman
ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY – I
Unit I.
Stereochemistry: a. Elements
of symmetry, simple axis of symmetry .
Notation, relative configuration and absolute configuration .Compounds with a
chiral carbon atom, compounds with other quadrivalent chiral atoms. Optical isomerism
in compounds containing no chiral atom, biphenyl, allenes, compounds with
exocylic double bonds and spirans.
b Chirality due to helical shape.. Cis /
Trans, E – Z isomerism resulting from double bonds, monocyclic compounds, fused
ring system. Racemic modifications and methods for resolution of racemic
mixtures. Asymmetric synthesis and stereo – selective synthesis.
Unit-II. a. Reactive Intermediates:
Definitions, generation, stability,
structure and reactivity of free
radicals carbocations, carbanions,
carbenes, Nitrenes/Nitrenium ions.
b. . Concepts of aromaticity and anti aromaticity, non benzenoid
aromatic compounds.
Unit-III. Mechanisms of
organic reactions: Free radical, Electrophilic, Nucleophilic reactions of aliphatic and aromatic compounds
Unit-IV. Elimination
Reactions: E1, E2, E1CB and E2CB
mechanisms, Mechanisms and orientation in Pyrolytic eliminations, effect of
substrate structure, Attacking base, leaving group and reaction bond, medium and reactivity addition to
carbon – carbon multiple bond reactions.
Mechanisms, Orientation and reactivity.
Unit-V. Electrocyclic,
pericyclic and sigmotropic reactions: introduction, terminology and
mechanism with suitable examples.
Recommended
Books
- Francis A. Carey & Richard J. Sunberg, Advanced Org. Chemistry , III rd Edition , Par B; Reactions and synthesis , Plenum Press, new York , London , Latest Edition.
- Eliel I. Ernest and Samuel h,
Stereochemistry of Org. Compounds, John Wiley and sons,
- Roland E. Lehr & Alan P Marchard, Orbital Symmetry: A Problem solving approach, Academic Press, New York Latest Edition.
- J. March , Advanced Org. Chemistry
, Reactions Mechanisms and Structure , 4th Edition, John Wiley & Sons ,
- I. L. Finar , Organic Chemistry , ELBS
- W. Carruthers, Some Modern Methods
of Org. Synthesis, III rd Edition,
ADVANCED MEDICINAL CHEMISTRY – I
Unit-I Theoretical Aspects of Drug Action
Types
of drug action, Physiochemical parameters and pharmacological activity, Non empirical Electronic
parameters, steric parameters and Stereo Chemical aspects of Drugs. Drug
Receptors, Receptor types and isolation, Drug Receptor Interaction, theories of
drug action, mechanism of drug action.
Unit-II Targets for the development of following
chemotherapeutic agents:
Anti-tubercular, Anti malarial , Anti – fungal, Immuno- modulators, Anti-
amoebic drugs.
Unit-III Targets for the
development of following pharmacodynamic agents –
Antiulcer,
Analgesic – Anti Inflammatory, Anti atherosclerotic, Anti- Angiogenesis, anti –
hypertensives.
Unit-IV Biotransformation of drugs- Prodrug approach, Soft Drug approach,
enzymes responsible for biotransformation, microsomal and non microsomal
mechanisms. Factors influencing enzyme induction and inhibition.
Unit-V Design of Local anesthetics, diuretics,
Anti- HIV, anticancer,
Introduction, general considerations on the development of new
drugs, classical and rational
procedures for the development of local anesthetics
Recommended Books
1.
Richard B. Silvermann, Org.
Chemistry of Drug Design and drug Action.
2.
Berger’s Medicinal Chemistry
and Drug Design. 6th Edition.
3.
Korolkovas Essentials of
Medicinal Chemistry
4.
Purcell Strategies of Drug
Design
5.
Alfred Berger Biochemical Basis
of Drug Design
6.
Corwin , Hansen Comprehensive
Medicinal Chemistry
7.
William O Foye Medicinal
Chemistry
8.
Testa B and Jenner P. Drug
Metabolism Chemical & Biochemical Aspects, Marcel Dekker
9.
Gyorgy Keri & Istdan Toth
Molecular Pathomechanism and New Trends in Drug Research, Taylor
10.
Ariens. Drug design medicinal
chemistry a series of monograph-volume 11- III, academic press, an imprint of
Elsevier pub.
ADVANCED MEDICINAL CHEMISTRY – II (Drug Design)
Unit-I
Genesis of New
Drugs: Serendipity, Random Screening, Extraction of active principles from Natural Sources, Molecular
Modification of Known Drugs, Selection or Synthesis of Soft Drugs, Drug
Latentiation and rational drug design
Unit-II
Rational Drug
Design: QSAR: Parameters involved in QSAR, lipophilicity (Polarisabiltiy,
electronic and steric parameters). Quantitative models. Hansch Analysis, Free
Wilson Analysis and their relationships, linear relationships and applications
of Hansch and Free Wilson Analysis.
Unit-III
Molecular Modeling: Introduction, molecular methods, Known receptors,
unknown receptors.
Unit-IV
Natural Products
as Leads for New Drugs
Introduction/History,
approaches to discovery and development of natural
products as
potential new drugs, selection and optimization of lead compounds for further
developments from CNS, anticancer antibiotics and cardiovascular drugs.
Unit-V
Structure based drug design :
Inhibitors of HIV-I Prokinase, Structural studies of HIV-I
Reverse transcriptase and implications for drug design, Bradykinin
receptor Antagonists, Design of purine nucleoside and Phosphorylase inhibitors,
Aldose Reductase Inhibitors, Thrombin inhibitors. Rhinoviral-Capsid-biding
Inhibitors.
Recommended Books :
1. Berger’s Medicinal Chemistry and Drug Design. 6th
Edition.
2. Korolkovas Essentials of Medicinal Chemistry
3. Purcell Strategies of Drug Design
4. Corwin , Hansen Comprehensive Medicinal Chemistry
5. William O Foye Medicinal Chemistry
6. Structure based Drug Design by Pandi Veerapandion.
ADVANCED
PHARMACEUTICAL ORGANIC CHEMISTRY PRACTICAL LAB-I
BASED ON THEORY AT LEAST 10 EXPERIMENTS
ADVANCED
MEDICINAL CHEMISTRY PRACTICAL LAB– I
BASED ON THEORY AT LEAST 10 EXPERIMENTS
