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Saturday, March 17, 2012

JNTU M. PHARMACY (PHARMACOLOGY) SYLLABUS


M. PHARMACY (PHARMACOLOGY)
COURSE STRUCTURE AND SYLLABUS

I YEAR  I SEMESTER
Code
Group
Subject
L
P
Credits


Modern Pharmaceutical Analytical Techniques
3
0
3


Advanced biostatistics and research methodology
3
0
3


Advanced Pharmacology – I       
3
0
3


Pharmacokinetics and Drug Metabolism            
3
0
3


Clinical Pharmacology and Pharmacotherapeutics
3
0
3

Lab
Modern Pharmaceutical Analytical Techniques Lab      
0
3
2

Lab
Advanced Pharmacology - I Lab  
0
3
2


Seminar
-
-
2


          Total Credits 


21


MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
(Common to all Branches)

Unit-I
A detailed study of separations and determination involved in the following chromatographic techniques.
  1. Column chromatography : Theory, preparation, procedures, methods of detection.
  2. This layer chromatography : Theory, preparation, procedures, detection of compounds
  3. Paper Chromatography : Theory, different techniques employed, filter papers used, quantitative and quantitative detections.
  4. Counter current extraction, soild phase extraction techniques.

Unit-II
  1. Gas chromatography: fundamentals, Instrumentation, columns preparation and operations, detection, derivitasation, LC-MS, GC-MS.
  2. HPLC : Principles and Instrumentations.

Unit-III
  1. UV-Visible Spectroscopy : Principle, Beer Lambert’s law, study and working principle of instrumentation, applications in pharmaceutical analysis and derivatives spectroscopy.
  2. IR Spectroscopy: Theory, different types of molecular vibrations, sampling techniques, instrumentation and applications in pharmaceutical analysis, FTIR
  3.  Flurorimetry:  Theory, fluorescence and chemical structure, factors affecting the fluorescence, study of working principles of the instrument and applications in pharmaceutical analysis.

Unit-IV
  1. NMR: theory, Chemical-shift, spin-spin coupling, shielding, working principle of instrumentations and applications in pharmaceutical analysis, HNMR, and cosy 13CNMR.
  2. Mass: principle, different methods of production of ions metastable ions, working principle of mass spectrometer and applications in pharmaceutical analysis.

Unit-V
  1. Differential thermal analysis, partial thermal analysis.
  2. Radiometric techniques, Radio immunoassay, Elisha test.
  3. X-ray diffraction, polarimetry.

Recommended Books:
1.     Munson J.W. “Pharmaceutical Analysis”; Mercel Dekker.
2.     Willard Dean Merrit “Instrumental Methods of Analysis”
3.     David underwood, Text Book of Quantitative analysis.
4.     Skogadwest, Instrumental methods of analysis.




ADVANCED BIOSTATISTICS AND RESEARCH METHODS

Unit-I :
Developing a research question, Resources for research question,
Literature Review: Traditional Qualitative Review
                                    Meta-Analysis—A Quantitative Review
Preparation of Research Proposal

Variables—Definition of Variable, Types of variables—Dependent and Independent variables, Confounded variables, Measurement of variables, Types of measurement scales and their comparison. Reliability and Validity of Measurements.

Unit-II :
Validity, Types of validity—Internal validity, Construct validity, External validity, Threats to validity. 

Control: Subject as own control (Within Subject control), Statistical control.

Unit-III:
Non-experimental Research:
Part 1—Observational, Archival and Case-Study Research: The Hermeneutic Approach. 
Observational Research: Naturalistic Observation, Participant-Observer Research.
Archival Research: Archival Data Collection and Compilation.
Case Studies:  Characteristic of Case Studies.  
 
Non-experimental Research: Survey Research—Designing of Questionnaire, Methods of Administration, Response Rates.  Types of Samples—Haphazard Samples, Purposive Samples, Convenience Samples and Probability Samples.  

Unit-IV :
True Experiments: Single-Factor Designs, Factors, Levels, Conditions, and Treatments.  Within-Subject Designs. 

True Experiments Part-2—Factorial Designs—Main Effects, Interactions, A Mixed Factorial Design. 

Unit V :
Single-Subject Experiments: Advantages and Disadvantages. 
Quasi Experiments: The differences between Quasi and True Experiments.
Design without Control Groups—Interrupted Time Series Designs and Repeated Treatment Designs. 

Text Books   
 1. Donald H. McBurney -Theresa L. White   “Research Methods” ( Cengage learning India Pvt. Ltd)
2. Statistics for business and economics 3rd edition by-Hooda-R.P- MC. Millan Business books
3. Biostatistics & Computer applications by GN Rao and NK Tiwari
Reference Books
1. Remingtons pharmaceutical Sciences
2.. Theory & Practice of  Industrial  Pharmacy by Lachman


ADVANCED PHARMACOLOGY – I

Unit-I
Drugs acting at Synaptic and neuro effector junctional sites.

A.    Autonomic & Somatic nervous systems.
B.    Muscarinic receptor agonists & antagonists.
C.    Anticholinesterases.
D.    Agents acting at Neuro Muscular Junction and autonomic ganglia.
E.    Sympathomimetic drugs, Catecholamines and Adrenergic antagonists.

Unit-II
Drugs acting on the Central Nervous System.

    1. Neurotransmission and CNS.
    2. Drugs used in the treatment of
1. Anxiety & Psychosis
2. Depression & Mania
3. Epilepsy
4. Migraine
5. CNS degenerative disorders
6. Parkinson’s Disease
7. Pain
    1. Drug addiction,dependence and abuse.

Unit-III
 Drugs affecting renal and cardiovascular function.

    1. Diuretics
    2. Renin & Angiotensin
    3. Drugs used in the treatment of
1. Myocardial Ischemia
2. Hypertension
3. CHF
4. Hyperlipidemia


Unit-IV
 Drugs acting on the blood & blood forming organs.

    1. Growth factors
    2. Anticoagulants, Thrombolytics & antiplatelet drugs.

Unit-V
Dermatological pharmacology,Vitamins & Chelating agents


Pharmacokinetics and Drug metabolism

Unit - I
Drug Absorption: Gastrointestinal, percutanceous and rectal kinetics and factors affecting drug absorption.

Unit - II
Drug Distribution: Plasma protein binding – factors affecting plasma protein binding – Tissue binding – transfer of drugs through biological barriers their therapeutic implication in drug action.


Unit - III
Elimination of drugs: Concept of renal clearance and excretion of drugs – biological
 half – life.

Unit - IV
Bioavalability of drug products: Bioavilability ests. Reaction of the body to foreign substances: Biotransoformation of drugs, phase I and phase II metabolic reactions.

Unit - V
Drug interaction: Pharmacokinetic, Pharmacodynamic drug interactions, Food drug and drink interactions food –herb drug interaction.



CLINICAL PHARMACOLOGY & PHARMACOTHERAPEUTICS

Unit-I
Principles of Pharacokinetics

A.    Revision of basic concepts.
B.    Clinical Pharmacokinetics.
i)                 Dose – response in man
ii)               Influence of renal and hepatic disease on Pharmacokinetics
iii)              Therapeutics drug monitoring
iv)             Population Pharmacokinetics.


Unit-II
           Adverse Drug Reactions, Drug Interactions and ADR monitoring.


Unit-III
Pathophysiology and drug therapy of the following disorders.

Schizophrenia, anxiety, depression, epilepsy, Parkinson’s, alzheimer’s diseases,   migraine, hypertension, angina pectoris, arrhythmias, atherosclerosis, myocardial infaraction, TB, leprosy, leukemia, solid tumors, lymphomas, psoriasis, respiratory, urinary, g.i. tract infections, endocarditis, fungal and HIV infection, rheumatoid arthritis, glaucoma, menstrual disorders, menopause.
Unit-IV
Drug therapy in

A.    Geriatrics
B.  Pediatrics
C.  Pregnancy & Lactation.

 Unit-V
 Pharmacogenetics : Inter-racial and individual variability in drugs metabolism.




MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES LAB
(Common to All Branches)

1. Use of spectrophotometer for analysis of Pharmacopoeial compounds and their formulations
2.Simultaneous determination of combination formulations (Minimum of 04 experiments)
3. Effect of pH and solvent on UV spectrum of certain drugs
4. Experiments of Chromatography
a.  Thin layer chromatography
   b.  Paper chromatography: Ascending, Descending, circular and two-dimensional techniques
     5. Experiments based on HPLC and GC
     6. IR, NMR and mass spectra: Interpretation for the structural elucidation of organic compounds
     7. Any other relevant experiments


Advanced Pharmacology - I Lab

3 comments:

  1. I WANT M.PHARM PHARMACOLOGY 2ND SEMISTER SYLLABUS
    CAN U PLEASE SEND IT

    ReplyDelete
  2. PLS ADD 2nd SEM SYLBS

    ReplyDelete
  3. thank u.can u pls send 2nd semister syllabus.

    ReplyDelete