M. PHARMACY (PHARMACOLOGY)
COURSE STRUCTURE AND SYLLABUS
I YEAR I SEMESTER
Code
|
Group
|
Subject
|
L
|
P
|
Credits
|
|
|
Modern Pharmaceutical Analytical
Techniques
|
3
|
0
|
3
|
|
|
Advanced
biostatistics and research methodology
|
3
|
0
|
3
|
|
|
Advanced
Pharmacology – I
|
3
|
0
|
3
|
|
|
Pharmacokinetics
and Drug Metabolism
|
3
|
0
|
3
|
|
|
Clinical
Pharmacology and Pharmacotherapeutics
|
3
|
0
|
3
|
|
Lab
|
Modern Pharmaceutical Analytical Techniques Lab
|
0
|
3
|
2
|
|
Lab
|
Advanced
Pharmacology - I Lab
|
0
|
3
|
2
|
|
|
Seminar
|
-
|
-
|
2
|
|
|
Total Credits
|
|
|
21
|
MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
(Common to all Branches)
Unit-I
A detailed study
of separations and determination involved in the following chromatographic
techniques.
- Column chromatography : Theory, preparation, procedures, methods of detection.
- This layer chromatography : Theory, preparation, procedures, detection of compounds
- Paper Chromatography : Theory, different techniques employed, filter papers used, quantitative and quantitative detections.
- Counter current extraction, soild phase extraction techniques.
Unit-II
- Gas chromatography: fundamentals, Instrumentation, columns preparation and operations, detection, derivitasation, LC-MS, GC-MS.
- HPLC : Principles and Instrumentations.
Unit-III
- UV-Visible Spectroscopy : Principle, Beer Lambert’s law, study and working principle of instrumentation, applications in pharmaceutical analysis and derivatives spectroscopy.
- IR Spectroscopy: Theory, different types of molecular vibrations, sampling techniques, instrumentation and applications in pharmaceutical analysis, FTIR
- Flurorimetry: Theory, fluorescence and chemical structure, factors affecting the fluorescence, study of working principles of the instrument and applications in pharmaceutical analysis.
Unit-IV
- NMR: theory, Chemical-shift, spin-spin coupling, shielding, working principle of instrumentations and applications in pharmaceutical analysis, HNMR, and cosy 13CNMR.
- Mass: principle, different methods of production of ions metastable ions, working principle of mass spectrometer and applications in pharmaceutical analysis.
Unit-V
- Differential thermal analysis, partial thermal analysis.
- Radiometric techniques, Radio immunoassay, Elisha test.
- X-ray diffraction, polarimetry.
Recommended
Books:
1.
Munson J.W. “Pharmaceutical
Analysis”; Mercel Dekker.
2.
Willard Dean Merrit
“Instrumental Methods of Analysis”
3.
David underwood, Text Book of
Quantitative analysis.
4.
Skogadwest, Instrumental
methods of analysis.
ADVANCED BIOSTATISTICS AND RESEARCH METHODS
Unit-I :
Developing a research question, Resources
for research question,
Literature Review: Traditional Qualitative
Review
Meta-Analysis—A
Quantitative Review
Preparation of Research Proposal
Variables—Definition of Variable, Types of
variables—Dependent and Independent variables, Confounded variables,
Measurement of variables, Types of measurement scales and their comparison.
Reliability and Validity of Measurements.
Unit-II :
Validity, Types of validity—Internal
validity, Construct validity, External validity, Threats to validity.
Control: Subject as own control (Within
Subject control), Statistical control.
Unit-III:
Non-experimental Research:
Part 1—Observational, Archival and
Case-Study Research: The Hermeneutic Approach.
Observational Research: Naturalistic
Observation, Participant-Observer Research.
Archival Research: Archival Data Collection
and Compilation.
Case Studies: Characteristic of Case Studies.
Non-experimental Research: Survey
Research—Designing of Questionnaire, Methods of Administration, Response
Rates. Types of Samples—Haphazard
Samples, Purposive Samples, Convenience Samples and Probability Samples.
Unit-IV :
True Experiments: Single-Factor Designs,
Factors, Levels, Conditions, and Treatments.
Within-Subject Designs.
True Experiments Part-2—Factorial
Designs—Main Effects, Interactions, A Mixed Factorial Design.
Unit V :
Single-Subject Experiments: Advantages and
Disadvantages.
Quasi Experiments: The differences between
Quasi and True Experiments.
Design without Control Groups—Interrupted
Time Series Designs and Repeated Treatment Designs.
Text Books
1. Donald H. McBurney -Theresa L. White “Research Methods” ( Cengage learning India Pvt. Ltd)
2. Statistics for
business and economics 3rd edition by-Hooda-R.P- MC. Millan Business
books
3. Biostatistics
& Computer applications by GN Rao and NK Tiwari
Reference Books
1. Remingtons
pharmaceutical Sciences
2.. Theory & Practice of Industrial
Pharmacy by Lachman
ADVANCED
PHARMACOLOGY –
I
Unit-I
Drugs acting at Synaptic and neuro
effector junctional sites.
A. Autonomic & Somatic
nervous systems.
B. Muscarinic receptor
agonists & antagonists.
C. Anticholinesterases.
D. Agents acting at Neuro
Muscular Junction and autonomic ganglia.
E. Sympathomimetic drugs,
Catecholamines and Adrenergic antagonists.
Unit-II
Drugs
acting on the Central Nervous System.
- Neurotransmission and
CNS.
- Drugs used in the
treatment of
1. Anxiety & Psychosis
2. Depression & Mania
3. Epilepsy
4. Migraine
5. CNS degenerative disorders
6. Parkinson’s Disease
7. Pain
- Drug
addiction,dependence and abuse.
Unit-III
Drugs affecting renal and cardiovascular
function.
- Diuretics
- Renin &
Angiotensin
- Drugs used in the
treatment of
1. Myocardial Ischemia
2. Hypertension
3. CHF
4. Hyperlipidemia
Unit-IV
Drugs acting on the blood & blood forming
organs.
- Growth factors
- Anticoagulants,
Thrombolytics & antiplatelet drugs.
Unit-V
Dermatological
pharmacology,Vitamins & Chelating agents
Pharmacokinetics
and Drug metabolism
Unit
- I
Drug Absorption: Gastrointestinal, percutanceous
and rectal kinetics and factors affecting drug absorption.
Unit
- II
Drug Distribution: Plasma protein
binding – factors affecting plasma protein binding – Tissue binding – transfer
of drugs through biological barriers their therapeutic implication in drug
action.
Unit
- III
Elimination of drugs: Concept of renal
clearance and excretion of drugs – biological
half – life.
Unit
- IV
Bioavalability of drug products:
Bioavilability ests. Reaction of the body to foreign substances: Biotransoformation
of drugs, phase I and phase II metabolic reactions.
Unit - V
Drug interaction: Pharmacokinetic,
Pharmacodynamic drug interactions, Food drug and drink interactions food –herb
drug interaction.
CLINICAL
PHARMACOLOGY & PHARMACOTHERAPEUTICS
Unit-I
Principles of Pharacokinetics
A.
Revision
of basic concepts.
B.
Clinical
Pharmacokinetics.
i)
Dose
– response in man
ii)
Influence
of renal and hepatic disease on Pharmacokinetics
iii)
Therapeutics
drug monitoring
iv)
Population
Pharmacokinetics.
Unit-II
Adverse Drug Reactions, Drug Interactions and
ADR monitoring.
Unit-III
Pathophysiology and drug therapy of
the following disorders.
Schizophrenia, anxiety, depression, epilepsy, Parkinson’s,
alzheimer’s diseases, migraine,
hypertension, angina pectoris, arrhythmias, atherosclerosis, myocardial
infaraction, TB, leprosy, leukemia, solid tumors, lymphomas, psoriasis,
respiratory, urinary, g.i. tract infections, endocarditis, fungal and HIV
infection, rheumatoid arthritis, glaucoma, menstrual disorders, menopause.
Unit-IV
Drug therapy in
A. Geriatrics
B.
Pediatrics
C.
Pregnancy & Lactation.
Unit-V
Pharmacogenetics : Inter-racial and individual
variability in drugs metabolism.
MODERN
PHARMACEUTICAL ANALYTICAL TECHNIQUES LAB
(Common
to All Branches)
1. Use of spectrophotometer for analysis of Pharmacopoeial compounds
and their formulations
2.Simultaneous determination of combination formulations (Minimum of
04 experiments)
3. Effect of pH and solvent on UV spectrum of certain drugs
4. Experiments of Chromatography
a. Thin layer
chromatography
b. Paper chromatography: Ascending, Descending,
circular and two-dimensional techniques
5. Experiments based on HPLC and GC
6. IR, NMR and mass spectra:
Interpretation for the structural elucidation of organic compounds
7. Any other relevant experiments
Advanced
Pharmacology - I Lab
I WANT M.PHARM PHARMACOLOGY 2ND SEMISTER SYLLABUS
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ReplyDeletethank u.can u pls send 2nd semister syllabus.
ReplyDeleteI WANT M.PHARM PHARMACOLOGY 2ND SEMISTER SYLLABUS
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iwant M.PHARM PHARMACOLOGY 2ND SEMISTER syllabus of 2012 batch
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